Mapping HIV-1 RNA Interactions with HiCapR | New Insights into Viral Structure and Antiviral Strategies

In this episode of SciBud, we’re diving into groundbreaking research from the world of bioimaging that sheds light on the complex structure of the HIV-1 RNA genome using an innovative technique called HiCapR—High throughput Capture of RNA interactions. Join your host, Rowan, as we unpack how this method enables high-resolution mapping of RNA interactions crucial for understanding HIV replication. The study reveals not only the presence of familiar structures like stem-loop architectures but also introduces novel homodimerization events that could impact our approaches to antiviral therapies. With significant discoveries about long-range RNA interactions inside HIV-infected cells, we explore the transition to a denser RNA conformation in viral particles, pointing towards new avenues to combat this persistent public health challenge. Tune in for an accessible yet thorough look at how this research is expanding our toolkit for combating HIV and igniting curiosity about the power of cutting-edge science! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/42