EPISODE · Mar 21, 2026 · 25 MIN
MCAS 101 - And What It Has to Do With Endo
from This EndoLife · host Jessica Duffin
Today I am continuing with my series on the trifecta of POTS, MCAS and h-EDS/hypermobile spectrum disorders and how they are connected to endo, and today we are basically doing a little MCAS 101.Affiliate PartnershipsmBIOTA - mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.DITTO - You can use the code: ENDOBELLY (all caps) for 20% off any and all orders, now and in the future. Need more help or want to learn how to work with me?Ways to work with me:One to one coaching info and application Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingMasterclasses in endo nutrition, surgery prep and recovery and pain reliefThis EndoLife, It Starts with Breakfast digital cookbookFree resources:This podcast! Endometriosis Net ColumnEndometriosis News ColumnSubstack InstagramReferences1) https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf, https://pubmed.ncbi.nlm.nih.gov/32324159/2) https://pmc.ncbi.nlm.nih.gov/articles/PMC12079877/ 3) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829454, https://jamanetwork.com/journals/jama/article-abstract/2828511 4) https://pubmed.ncbi.nlm.nih.gov/24098785/ 5) https://pmc.ncbi.nlm.nih.gov/articles/PMC8459548/, https://www.sciencedirect.com/science/article/pii/S1201971220307323 6) https://pubmed.ncbi.nlm.nih.gov/34166845/, https://pubmed.ncbi.nlm.nih.gov/35623575/, https://pubmed.ncbi.nlm.nih.gov/32324159/ 7) https://braininflammation.org/mast-cell-activation-syndrome-mcas-dr-lawrence-afrin/ 8) https://pmc.ncbi.nlm.nih.gov/articles/PMC1797832/ , https://pmc.ncbi.nlm.nih.gov/articles/PMC2603032/9) https://pubmed.ncbi.nlm.nih.gov/7588332/10) https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf, https://www.degruyterbrill.com/document/doi/10.1515/dx-2020-0005/html11) https://pubmed.ncbi.nlm.nih.gov/29074615/,https://pmc.ncbi.nlm.nih.gov/articles/PMC9945179/,https://pubmed.ncbi.nlm.nih.gov/36016927/,https://pubmed.ncbi.nlm.nih.gov/15494048/,https://pubmed.ncbi.nlm.nih.gov/27841046,https://pubmed.ncbi.nlm.nih.gov/26550518/,https://pubmed.ncbi.nlm.nih.gov/17631002/,https://pubmed.ncbi.nlm.nih.gov/40028674,https://pubmed.ncbi.nlm.nih.gov/34630429/,https://pmc.ncbi.nlm.nih.gov/articles/PMC6964357/, https://pubmed.ncbi.nlm.nih.gov/37664916/12) https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1727183/full13) https://pubmed.ncbi.nlm.nih.gov/22369407/, https://pubmed.ncbi.nlm.nih.gov/24857310/, https://www.nichd.nih.gov/newsroom/releases/endometriosis, https://www.ejog.org/article/S0301-2115(14)00234-6/abstract14) https://pubmed.ncbi.nlm.nih.gov/39990556/, https://jchr.org/index.php/JCHR/article/view/5363, https://pmc.ncbi.nlm.nih.gov/articles/PMC3413773/15) https://pmc.ncbi.nlm.nih.gov/articles/PMC11348541/, https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf16) https://pmc.ncbi.nlm.nih.gov/articles/PMC7282488/17) https://ard.bmj.com/content/80/Suppl_1/965.1, https://pubmed.ncbi.nlm.nih.gov/35449490/, https://pmc.ncbi.nlm.nih.gov/articles/PMC9022617/ 18) https://www.ahajournals.org/doi/10.1161/JAHA.121.021002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed19) https://pmc.ncbi.nlm.nih.gov/articles/PMC11348541/#sec14
What this episode covers
Today I am continuing with my series on the trifecta of POTS, MCAS and h-EDS/hypermobile spectrum disorders and how they are connected to endo, and today we are basically doing a little MCAS 101.Affiliate PartnershipsmBIOTA - mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.DITTO - You can use the code: ENDOBELLY (all caps) for 20% off any and all orders, now and in the future. Need more help or want to learn how to work with me?Ways to work with me:One to one coaching info and application Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingMasterclasses in endo nutrition, surgery prep and recovery and pain reliefThis EndoLife, It Starts with Breakfast digital cookbookFree resources:This podcast! Endometriosis Net ColumnEndometriosis News ColumnSubstack InstagramReferences1) https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf, https://pubmed.ncbi.nlm.nih.gov/32324159/2) https://pmc.ncbi.nlm.nih.gov/articles/PMC12079877/ 3) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829454, https://jamanetwork.com/journals/jama/article-abstract/2828511 4) https://pubmed.ncbi.nlm.nih.gov/24098785/ 5) https://pmc.ncbi.nlm.nih.gov/articles/PMC8459548/, https://www.sciencedirect.com/science/article/pii/S1201971220307323 6) https://pubmed.ncbi.nlm.nih.gov/34166845/, https://pubmed.ncbi.nlm.nih.gov/35623575/, https://pubmed.ncbi.nlm.nih.gov/32324159/ 7) https://braininflammation.org/mast-cell-activation-syndrome-mcas-dr-lawrence-afrin/ 8) https://pmc.ncbi.nlm.nih.gov/articles/PMC1797832/ , https://pmc.ncbi.nlm.nih.gov/articles/PMC2603032/9) https://pubmed.ncbi.nlm.nih.gov/7588332/10) https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf, https://www.degruyterbrill.com/document/doi/10.1515/dx-2020-0005/html11) https://pubmed.ncbi.nlm.nih.gov/29074615/,https://pmc.ncbi.nlm.nih.gov/articles/PMC9945179/,https://pubmed.ncbi.nlm.nih.gov/36016927/,https://pubmed.ncbi.nlm.nih.gov/15494048/,https://pubmed.ncbi.nlm.nih.gov/27841046,https://pubmed.ncbi.nlm.nih.gov/26550518/,https://pubmed.ncbi.nlm.nih.gov/17631002/,https://pubmed.ncbi.nlm.nih.gov/40028674,https://pubmed.ncbi.nlm.nih.gov/34630429/,https://pmc.ncbi.nlm.nih.gov/articles/PMC6964357/, https://pubmed.ncbi.nlm.nih.gov/37664916/12) https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1727183/full13) https://pubmed.ncbi.nlm.nih.gov/22369407/, https://pubmed.ncbi.nlm.nih.gov/24857310/, https://www.nichd.nih.gov/newsroom/releases/endometriosis, https://www.ejog.org/article/S0301-2115(14)00234-6/abstract14) https://pubmed.ncbi.nlm.nih.gov/39990556/, https://jchr.org/index.php/JCHR/article/view/5363, https://pmc.ncbi.nlm.nih.gov/articles/PMC3413773/15) https://pmc.ncbi.nlm.nih.gov/articles/PMC11348541/, https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf16) https://pmc.ncbi.nlm.nih.gov/articles/PMC7282488/17) https://ard.bmj.com/content/80/Suppl_1/965.1, https://pubmed.ncbi.nlm.nih.gov/35449490/, https://pmc.ncbi.nlm.nih.gov/articles/PMC9022617/ 18) https://www.ahajournals.org/doi/10.1161/JAHA.121.021002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed19) https://pmc.ncbi.nlm.nih.gov/articles/PMC11348541/#sec14
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MCAS 101 - And What It Has to Do With Endo
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