Meet Dr Emmanuelle Vire, University College London

Last week we attended the Alzheimer's Research UK Conference in Brighton. We took time out from the programme to talk with early career dementia researchers to ask them about their work, the challenges they have faced and how they overcame them, and to share a highlight from the conference. In this short interview we talk with Dr Emmanuelle Vire, Associate Professor in the University College London Institute of Prion Diseases. Emmanuelle explores if epigenetics is a hallmark of protein-based inheritance in neurodegeneration. Our research specifically investigates epigenetic mechanisms in human prion diseases. Emmanuelle and her colleagues employ a large array of technologies (transcriptomics, epigenomics, cell-based assays, animal models, patients samples) to determine if, where, when and how epigenetics contribute to disease susceptibility, onset, and progression. Using next-generation technologies we profile DNA, RNA, and histone modifications and identify disease-specific gene (coding and non-coding) signatures and pathways. Some their current projects also involve machine learning, nanopore sequencing, small molecule inhibitor and genome editing. Find out more about Emmanuelle and her work on our website: https://www.dementiaresearcher.nihr.ac.uk/profile-dr-emmanuelle-vire-university-college-london/ If you would like to join us and add your profile and short interview to our researchers profile, drop us a line to [email protected]