Metabolic stress remodelling systemic sclerosis (scleroderma)

In this #ArthritisAtHome, we are sharing the #CRAthritis interview with Ms. Lamia Khan, a PhD Candidate in the Rheumatology Division of the Department of Medicine at the University of Alberta. A recent study she was involved in found that severe systemic sclerosis patients develop DNA breaks in skin cells, leading to mutations. In her discussion with Ellen Wang, ACE’s Programs Coordinator, Lamia defines what metabolic stress remodelling is and share insights into the roles of fibrosis causing molecules called Foxo1 in promoting cancer-like changes in systemic sclerosis. She concludes with some tips on self-advocacy for people living with scleroderma. Additional learning resourcesRole of metabolic stress for enhancing muscle adaptations: Practical applicationsArthritis Consumer Experts’ About Scleroderma pageScleroderma Canada