Metformin - A Biguanide for Type 2 Diabetes: Pharmacology Made Easy episode artwork

EPISODE · Jan 26, 2026 · 32 MIN

Metformin - A Biguanide for Type 2 Diabetes: Pharmacology Made Easy

from This Is Why with Dr. Busti · host Anthony Busti, MD, PharmD, MSc, FNLA, FAHA

Metformin is a first-line oral medication for type 2 diabetes.  In this lecture from This is Why, Dr. Busti will explain how metformin works to lower the A1c and help patients with type 2 diabetes get to their A1C goals. You’ll learn how to:- Metformin mechanism of action (MOA): how biguanides lower glucose and improve insulin resistance- Where metformin fits in type 2 diabetes therapy (first-line option and combination use)- Key clinical benefits (A1C lowering, weight neutrality/possible weight loss)- Dosing basics and titration strategies (including extended-release considerations)- High-yield adverse effects: GI effects, vitamin B12 concerns, and the real story on lactic acidosis- Contraindications and precautions (renal function, acute illness, contrast studies, alcohol use)- Monitoring and patient counseling points you should know for practice and examThe goal = make medical education easy and clinically relevant.👉 Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/metformin-biguanide-type-2-diabetes-pharmacology👉 Get more with a free membership at https://www.thisiswhy.health/- Access free downloads from our videos - Access deep dive content from Dr. Busti- Organize content via playlists & collections- Join live Q&A- Receive member newsletters- Coupons & discounts for exam prep resources👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!#metformin #type2diabetes #diabetespharmacology #biguanide #bustiDisclaimer:This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

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Metformin is a first-line oral medication for type 2 diabetes. In this lecture from This is Why, Dr. Busti will explain how metformin works to lower the A1c and help patients with type 2 diabetes get to their A1C goals. You’ll learn how to: - Metformin mechanism of action (MOA): how biguanides lower glucose and improve insulin resistance - Where metformin fits in type 2 diabetes therapy (first-line option and combination use) - Key clinical benefits (A1C lowering, weight neutrali...

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Metformin - A Biguanide for Type 2 Diabetes: Pharmacology Made Easy

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