Methotrexate Explained: Weekly Dosing, Folic Acid & Safety

In this episode of OSCE Talk, we break down methotrexate — a high-risk but commonly prescribed DMARD used in conditions such as rheumatoid arthritis, psoriatic arthritis, and Crohn’s disease.We explain:how methotrexate workswhy it is taken once weekly (and never daily)the role of folic acidkey side effects, drug interactions, and monitoringimportant counselling points around infection risk, pregnancy, and safety-nettingClear, practical explanations you can use on the ward, in clinic, and in exams.