Methyl to the Membrane

What this episode covers

This release contains only the music track from Base by Base Episode 370. Song title: Methyl to the MembraneOriginal Base by Base episode: 370: ICMT and INPP5E enable BRAFV600E tumor growth Article metadata:Article title: ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5EJournal: Proceedings of the National Academy of SciencesDOI: 10.1073/pnas.2601795123Reference: Yang X, Qiao X, Schmidt S, et al. ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E. PNAS. 2026;123(20):e2601795123. doi:10.1073/pnas.2601795123 Lyrics:Verse 1Neon in the lab, the numbers won’t lieA single hot switch, and the shadows multiplyCells on the run with a fire in their codeBut every fast escape leaves a trace on the road Pre-ChorusThere’s a tiny mark where the story turnsA quiet enzyme and the pressure burnsIf the anchor slips, the signal fadesAnd the invader stalls in the light it made ChorusPut the methyl to the membrane, let it hold or breakCut the tether, watch the crash, feel the pathway shakeWhen the surface won’t receive what it used to takeThe growth can’t find its rhythm, it’s a storm on a lake Verse 2CAAX at the end like a tag on a threadPulled to the edge where the living is fedINPP5E rides where the lipids glowIf it can’t dock in, it can’t keep the flow BridgeAnd PI(4,5)P2 rises like a tideChanging the shoreline where the killers hideEven when resistance says “I’m here to stay”A new kind of block can get in the way Final ChorusPut the methyl to the membrane, let it hold or breakCut the tether, watch the crash, feel the pathway shakeWhen the surface won’t receive what it used to takeThe growth can’t find its rhythm—now it’s wide awake

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