Michael Dunne: Confronting the Antibiotic Resistance Crisis

Howie and Harlan are joined by infectious disease specialist Michael Dunne to discuss the growing problem of antimicrobial resistance and what's needed to incentivize the development of new antibiotics. Harlan reflects on the controversy sparked by the release of his study on post-vaccination syndrome; Howie provides an update on the measles outbreak in Texas.  Links: Post-Vaccine Syndrome Harlan Krumholz: "Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination" "A small study on Covid vaccine safety sparks an online tempest" "Scientists Describe Rare Syndrome Following Covid Vaccinations" Antimicrobial Resistance and New Antibiotics "New bill would create a subscription payment model to jumpstart antibiotic development" Antimicrobials Working Group H.R.4127—DISARM Act of 2021 S.1355—PASTEUR Act of 2023 CDC: Antimicrobial Resistance Facts and Stats Michael Dunne: "Impact of Empirical Antibiotic Therapy on Outcomes of Outpatient Urinary Tract Infection Due to Nonsusceptible Enterobacterales" Michael Dunne: "A multicenter analysis of trends in resistance in urinary Enterobacterales isolates from ambulatory patients in the United States: 2011-2020" CDC: Core Elements of Antibiotic Stewardship "Crisis Looms in Antibiotics as Drug Makers Go Bankrupt" "Bill & Melinda Gates Medical Research Institute Initiates Phase 3 Clinical Trial of Tuberculosis Vaccine Candidate" Michael Dunne: "Replacing serum with dried blood microsampling for pharmacokinetics, viral neutralisation and immunogenicity bioanalysis supporting future paediatric development of RSM01, a candidate respiratory syncytial virus neutralising monoclonal antibody" The Measles Outbreak "An unvaccinated child has died in the Texas measles outbreak" CDC: Measles, Mumps, Rubella (MMR) Vaccine Safety WHO: Measles "Consequences of Undervaccination—Measles Outbreak, New York City, 2018-2019" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.