Microplastics, Bile, and Cellular Aging

In this 187th episode, I discuss what microplastics have to do with bile, gallstones, mitochondria, and cellular aging. In this episode, we explore emerging research detecting microplastics in human bile—and the higher concentrations found in people with gallstones.We’ll discuss how these particles may interact with biliary cells, contribute to mitochondrial stress, and promote a senescence-like “zombie cell” state. We’ll also examine experimental findings on melatonin’s potential to protect mitochondrial function, while considering why healthy sleep may be more important than relying on supplementation.From a functional medicine perspective, the conversation focuses on reducing avoidable plastic exposure, supporting liver and biliary function, maintaining healthy detoxification pathways, and building resilience through nutrition, movement, stress management, and restorative sleep.Reference:Zhan L, Fu L, Zeng Q, Liang R, Tang J, Liu J, Qian B, Xu Z,Che L. Microplastics accumulate in human bile and drive cholangiocytesenescence. Environ Sci Ecotechnol. 2026;31:100686.doi:10.1016/j.ese.2026.100686.