Mind the Gap - Update on Global TB Goals

Today I had the privilege of speak with Professor Christoph Lange, Secretary General of the Union, founding chairman of TBNet and is the clinical lead for the Unite4TB Consortium. Professor Lange spoke to us about where we're up to with our EndTB Goals. Professor Lange spoke about the significant barriers that remain, where our shortfalls have come, where our successes have arisen, and what exciting opportunities lay in the years ahead for tuberculosis.REFERENCESLange, Christoph, et al. "Perspective for precision medicine for tuberculosis." Frontiers in Immunology 11 (2020): 566608Lange, Christoph, et al. "Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement." (2014): 23-63.Günther, Gunar, et al. "Relative cost of multidrug-resistant TB medicines in Europe." The international journal of tuberculosis and lung disease 27.5 (2023): 341-344.Koehler, Niklas, et al. "Pretomanid-resistant tuberculosis." Journal of Infection 86.5 (2023): 520-524.Domínguez, José, et al. "Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement." The Lancet Infectious Diseases 23.4 (2023): e122-e137.Heyckendorf, Jan, et al. "Method for diagnosis and treatment monitoring and individual therapy end decision in tuberculosis infection." U.S. Patent Application No. 17/904,544Villar-Hernández, Raquel, et al. "Tuberculosis: current challenges and beyond." Breathe 19.1 (2023)Günther, Gunar, et al. "Availability and costs of medicines for the treatment of tuberculosis in Europe." Clinical microbiology and infection 29.1 (2023): 77-84DiNardo, Andrew R., et al. "Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes." European Respiratory Journal 60.3 (2022).Günther, Gunar, et al. "Cost and availability of drugs and treatment regimens and availability of drug resistance testing for tuberculosis in Europe." medRxiv (2022): 2022-02Boeree, M. J., et al. "UNITE4TB: a new consortium for clinical drug and regimen development for TB." The International Journal of Tuberculosis and Lung Disease 25.11 (2021): 886Lönnroth, Knut, N. Sarita Shah, and Christoph Lange. "State-of-the-art series on tuberculosis and migration." The international journal of tuberculosis and lung disease 20.10 (2016): 1280-1281.DiNardo, Andrew R., et al. "Tuberculosis endotypes to guide stratified host-directed therapy." Med 2.3 (2021): 217-232.