Mini-Puberty: What Can You Still Learn Before the Axis Goes Quiet? | S5E5

Mini-puberty is often reduced to a transient testosterone surge. Clinically, it is much more useful to think of it as a temporary systems-level test of the reproductive axis.In this episode of Pediatric Urology Academy, we examine how LH and FSH, Leydig-cell markers, Sertoli-cell markers, and the infant phenotype can be integrated to distinguish different mechanisms of gonadal dysfunction.The discussion focuses on micropenis, bilateral cryptorchidism, bilateral nonpalpable testes, congenital hypogonadotropic hypogonadism, and the diagnostic value of AMH and inhibin B when the classic testosterone window has begun to fade.We also examine an important controversy: whether abnormal mini-puberty truly explains impaired germ-cell development in cryptorchid boys, and how far the evidence supports hormonal treatment in infancy.The central message is simple:Mini-puberty is not one hormone peak.There is no single mini-puberty clock.And in infancy, time is part of the test itself.Pediatric Urology AcademyHosted by Amin Afrasiabi, MD.