Molecular and cellular deconstruction of metastatic osteosarcoma

Dr. Troy McEachron joined us on OsteoBites to discuss the molecular and cellular deconstruction of metastatic osteosarcoma. Immunotherapy holds great promise for a subset of patients whose tumors respond to this innovative and remarkable approach. The therapeutic benefit for patients with osteosarcoma has been largely underwhelming, prompting clinical, translational, and basic scientists to ask why. Dr. McEachron's laboratory is focused on understanding the oncogenic and immunoregulatory mechanisms within the metastatic osteosarcoma microenvironment and how they impact therapeutic efficacy. He discusses his lab's current work in using various -omic technologies to deconstruct metastatic osteosarcoma.Dr. McEachron earned his doctorate in Molecular and Cellular Pathology from the University of North Carolina at Chapel Hill in 2011. He completed postdoctoral fellowships at St. Jude Children’s Research Hospital and at the Translational Genomics Research Institute. In 2016, Dr. McEachron joined the faculty of the Keck School of Medicine at the University of Southern California as an Assistant Professor in the Department of Translational Genomics (primary appointment) and the Department of Pediatrics (secondary appointment). Dr. McEachron joined the Pediatric Oncology Branch of the National Cancer Institute in 2021 where he leads the Integrated Solid Tumor Biology Section. The major focus of his laboratory is to molecularly dissect the microenvironment of pediatric metastatic osteosarcoma to better understand the biology of metastatic disease and identify therapeutically actionable targets.