mRNA Systemic Toxicity: How Untargeted Lipid Nanoparticles Force MHC-I Antigen Display and Trigger Inescapable CD8+ Autoimmune Assassination

Explore the unassailable cellular biophysics behind mRNA-induced myocarditis (heart inflammation), detailing exactly how systemic lipid nanoparticles (fatty delivery vehicles) hijack ApoE routing (bloodstream GPS) to infiltrate non-regenerative cardiomyocytes (heart muscle cells), forcing them to display foreign antigens (immune targets) on MHC-I receptors (cellular display windows) and guaranteeing permanent fibrotic scarring via CD8+ T-cell (killer immune cell) execution.