MSK: Mononeuritis Multiplex: Free MSRA Podcast

⚕️ FREE MSRA PODCAST – Mononeuritis Multiplex🎧 A scattered nerve disorder that screams “look deeper” – perfect for tackling those tricky MSRA differentials and real-life neurology cases.🧠 Key Learning Points📌 Definition• Damage to two or more non-adjacent peripheral nerves• Distinct from polyneuropathy – think “patchy power cuts”📌 Causes & Risk Factors• Most often due to vasculitis (e.g. polyarteritis nodosa)• Other culprits:Diabetes mellitusHepatitis B/C, HIVAutoimmune diseases (RA, SLE)Malignancy (e.g. lymphoma)Hereditary neuropathies🧠 Mnemonic: DIV HAM = Diabetes, Infection, Vasculitis, Hereditary, Autoimmune, Malignancy📌 Pathophysiology• Ischaemic nerve injury from inflamed vessels• Can involve axonal degeneration or demyelination• Autoimmunity & infection both contribute (direct or immune-mediated)📌 Symptoms• Asymmetric weakness + sensory loss in different limbs• Sharp pain or paraesthesia in nerve distributions• Progresses over days to weeks🧠 Memory Tip: Multiple nerves, multiple places, multiple problems📌 Differential Diagnosis• Polyneuropathy (symmetric glove-stocking pattern)• Radiculopathy (nerve root compression)• Single nerve palsy (e.g. carpal tunnel)📌 Diagnosis• Nerve conduction studies (NCS) – patchy nerve involvement• Electromyography (EMG) – shows denervation• Bloods: inflammatory markers, ANA, ANCA, HIV, Hep B/C• May need MRI or nerve biopsy🧠 Tip: NCS = wiring, EMG = appliance function📌 Management• Treat the underlying cause:Immunosuppressants (e.g. steroids) for vasculitisAntivirals for hepatitisOptimise glucose in diabetes• Pain control: NSAIDs, anticonvulsants• Physio & OT for function and adaptation• Requires multidisciplinary care📌 Complications• Permanent nerve damage• Chronic pain• Functional disability affecting limbs or daily living📌 Prognosis• Variable – early treatment of the cause = best outcomes• Nerve regeneration is slow and often incomplete• Delay = disability – early recognition is key!📎 More MSRA Resources for Mononeuritis Multiplex📝 Revision Notes:https://www.passthemsra.com/topic/mononeuritis-multiplex-revision-notes/🧠 Flashcards:https://www.passthemsra.com/topic/mononeuritis-multiplex-flashcards/💬 Accordion Q&A Notes:https://www.passthemsra.com/topic/mononeuritis-multiplex-accordion-qa-notes/🚀 Rapid Quiz:https://www.passthemsra.com/topic/mononeuritis-multiplex-rapid-quiz/🎯 Quiz Page:https://www.passthemsra.com/quizzes/mononeuritis-multiplex/🎓 Full Course:https://www.passthemsra.com/courses/msk-for-the-msra/#MSRA #MSRARevision #MononeuritisMultiplex #MSRAFlashcards #MSRAQuiz #MSRAQANotes #MSRAAccordions #MSKforMSRA #NeurologyForMSRA #PassTheMSRA #FreeMSRA #MSRAQuestionBank