MSK: Rhabdomyolysis: Free MSRA Podcast

⚡️ FREE MSRA PODCAST – Rhabdomyolysis🎧 In this high-yield Deep Dive, we break down the breakdown… of muscle! 🧠 Learn everything you need to know about rhabdomyolysis, a life-threatening MSK emergency that can lead to kidney damage, electrolyte chaos, and cardiac arrest 💥🩸🧠 Key Learning Points📌 Definition• Rhabdomyolysis = skeletal muscle breakdown → intracellular contents leak into bloodstream• Releases myoglobin, creatine kinase (CK), potassium, phosphate 💥📌 Mnemonic: METRICM – Muscle Injury 🥊E – Extreme exertion 🏃‍♂️T – Toxins & meds (statins, alcohol, cocaine) 💊R – Reduced blood flow 🛏️I – Infections (e.g. influenza) 🤒C – Conditions (e.g. myositis, metabolic myopathies) 🧬📌 Pathophysiology• Damaged muscle → massive CK and myoglobin release• Myoglobin precipitates in kidneys → acute kidney injury (AKI) 🚨• Hyperkalaemia, hypocalcaemia, and metabolic acidosis may follow📌 Symptoms• Muscle pain, swelling, weakness 💪• Dark urine (tea/cola coloured) ☕• Fatigue, confusion, low urine output🧠 Classic triad: pain, weakness, dark urine📌 Investigations• 🚨 CK: >5× normal (often >1000 IU/L)• Urine dip: positive for “blood” but no RBCs (myoglobinuria)• U&Es: assess renal function, potassium, calcium• ⚠️ Rule out compartment syndrome, AKI, myositis📌 Complications• AKI (commonest & most dangerous)• Hyperkalaemia → arrhythmias 🫀• Hypocalcaemia, hyperphosphataemia• Disseminated intravascular coagulation (DIC) 🩸• Compartment syndrome, metabolic acidosis📌 Management• 🔑 IV fluids – aggressive hydration is the cornerstone 💧💧• Correct electrolytes – esp. potassium• Stop causative drugs (e.g. statins) ❌• Dialysis if severe AKI or resistant hyperkalaemia• 💊 Consider sodium bicarbonate (alkalinise urine), diuretics cautiously🧠 Hyperkalaemia emergency? → IV calcium gluconate, insulin+dextrose, salbutamol📌 Prognosis• ✅ Good with early recognition & treatment• ❗ Poor if diagnosis is delayed, severe AKI, or arrhythmias develop• Some may develop CKD, persistent weakness, or fatigue📌 Statin-induced Rhabdo• Rare but serious 📉• Risk ↑ with age, high doses, drug interactions (fibrates, macrolides)• Always check CK + stop statin if myalgia + dark urine📚 Useful MSRA Revision Resources📝 Revision Notes:https://www.passthemsra.com/topic/rhabdomyolysis-revision-notes-2/🧠 Flashcards:https://www.passthemsra.com/topic/rhabdomyolysis-flashcards-2/💬 Accordion Q&A Notes:https://www.passthemsra.com/topic/rhabdomyolysis-accordion-qa-notes/🚀 Rapid Quiz:https://www.passthemsra.com/topic/rhabdomyolysis-rapid-quiz/🎯 Quiz Page:https://www.passthemsra.com/quizzes/rhabdomyolysis/🦴 Full MSK Course:https://www.passthemsra.com/courses/msk-for-the-msra/#MSRA #MSRARevision #Rhabdomyolysis #RhabdoMSRA #MSRAFlashcards #MSRAQuiz #MSRAQANotes #MSRAAccordions #MSKforMSRA #ElectrolyteEmergency #AKI #PassTheMSRA