Nancy Guthrie Case: Expert Says Suspect Likely Left Saliva DNA in the House episode artwork

EPISODE · Mar 16, 2026 · 56 MIN

Nancy Guthrie Case: Expert Says Suspect Likely Left Saliva DNA in the House

from The Truth of the Matter with Natasha Zouves · host Natasha Zouves

An 84-year-old woman disappears from her home, blood found on the doorstep. Foreign DNA is discovered inside the house, but it’s a mixed sample. And more than a month later, investigators still don’t have a suspect.   In this episode of “The Truth of the Matter Podcast,” Natasha Zouves sits down with one of the most prominent genetic genealogists in the world, CeCe Moore, the forensic expert who has helped solve more than 300 cases using DNA. Moore breaks down what investigators are really dealing with in the Nancy Guthrie disappearance, and why the DNA evidence may be far more complicated than the public realizes.   Among the revelations in this interview: • Moore believes the technology needed to separate the mixed DNA sample may not exist yet • Why police cannot simply search the largest 23andMe or Ancestry databases • The loophole investigators used in the Bryan Kohberger / Idaho murders case that no longer exists • Why Moore believes investigators should re-swab the Guthrie home right now  •And why she believes the case could turn on the discovery of a second crime scene   Investigative genetic genealogy helped identify the Golden State Killer and helped lead police to Bryan Kohberger in the Idaho student murders. Moore believes genetic genealogy will solve this case — and talks about the path to get there.   Watch the podcast episode here https://www.youtube.com/watch?v=o9ZVEOWc9q0&list=PL6PrA6lo8rJIaFbc0VZfFz4xcY8d6vaR6&index=2   Follow the podcast on IG: https://www.instagram.com/truthofthematterpod/   The Truth of the Matter with Natasha Zouves isn’t just another podcast — it’s a fight to uncover what powerful institutions want hidden. From secret human experiments the government carried out on unsuspecting citizens to toxic cover-ups poisoning communities, Emmy and Murrow Award-winning journalist Natasha Zouves brings you the stories people in power don’t want told. Each week, we expose evidence buried in archives, amplify the voices of those who’ve been silenced, and hold the powerful accountable. From radioactive “oatmeal experiments” on children, to cancer causing chemicals destroying farms, to veterans erased from history — these are the stories that matter. This is journalism that refuses to look away. The Truth of the Matter is about transparency, and justice for the people left behind.   You can find “The Truth of the Matter” wherever you listen to your podcasts: https://podcasts.apple.com/us/podcast/the-truth-of-the-matter-with-natasha-zouves/id1804707066 https://open.spotify.com/show/2iQ85VHlMmBfLBaTtSp8tF     Connect with host Natasha Zouves

An 84-year-old woman disappears from her home, blood found on the doorstep. Foreign DNA is discovered inside the house, but it’s a mixed sample. And more than a month later, investigators still don’t have a suspect.   In this episode of “The Truth of the Matter Podcast,” Natasha Zouves sits down with one of the most prominent genetic genealogists in the world, CeCe Moore, the forensic expert who has helped solve more than 300 cases using DNA. Moore breaks down what investigators are really dealing with in the Nancy Guthrie disappearance, and why the DNA evidence may be far more complicated than the public realizes.   Among the revelations in this interview: • Moore believes the technology needed to separate the mixed DNA sample may not exist yet • Why police cannot simply search the largest 23andMe or Ancestry databases • The loophole investigators used in the Bryan Kohberger / Idaho murders case that no longer exists • Why Moore believes investigators should re-swab the Guthrie home right now  •And why she believes the case could turn on the discovery of a second crime scene   Investigative genetic genealogy helped identify the Golden State Killer and helped lead police to Bryan Kohberger in the Idaho student murders. Moore believes genetic genealogy will solve this case — and talks about the path to get there.   Watch the podcast episode here https://www.youtube.com/watch?v=o9ZVEOWc9q0&list=PL6PrA6lo8rJIaFbc0VZfFz4xcY8d6vaR6&index=2   Follow the podcast on IG: https://www.instagram.com/truthofthematterpod/   The Truth of the Matter with Natasha Zouves isn’t just another podcast — it’s a fight to uncover what powerful institutions want hidden. From secret human experiments the government carried out on unsuspecting citizens to toxic cover-ups poisoning communities, Emmy and Murrow Award-winning journalist Natasha Zouves brings you the stories people in power don’t want told. Each week, we expose evidence buried in archives, amplify the voices of those who’ve been silenced, and hold the powerful accountable. From radioactive “oatmeal experiments” on children, to cancer causing chemicals destroying farms, to veterans erased from history — these are the stories that matter. This is journalism that refuses to look away. The Truth of the Matter is about transparency, and justice for the people left behind.   You can find “The Truth of the Matter” wherever you listen to your podcasts: https://podcasts.apple.com/us/podcast/the-truth-of-the-matter-with-natasha-zouves/id1804707066 https://open.spotify.com/show/2iQ85VHlMmBfLBaTtSp8tF     Connect with host Natasha Zouves

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Nancy Guthrie Case: Expert Says Suspect Likely Left Saliva DNA in the House

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This episode was published on March 16, 2026.

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An 84-year-old woman disappears from her home, blood found on the doorstep. Foreign DNA is discovered inside the house, but it’s a mixed sample. And more than a month later, investigators still don’t have a suspect.   In this episode of “The Truth...

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