Neddylation: The Hidden Switch of Neuronal Aging with Dr.Nathalie Saurat

from Decoding Longevity · host Raghav Sehgal

What if aging in brain cells could be switched on—or reversed? In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques speak with Dr. Nathalie Saurat about her groundbreaking CRISPR screen revealing neddylation as a critical regulator of neuronal aging, Alzheimer’s disease progression, and protein turnover.You’ll learn how Nathalie:Generated 2.8 billion human stem-cell-derived neurons to uncover aging pathwaysDiscovered how inhibiting neddylation mimics age-related changes like tau aggregation, DNA damage, and loss of protein quality controlExplores ways to program age into neurons for better drug discovery in late-onset neurodegenerative diseases🎧 Perfect for listeners curious about aging biology, neurodegeneration, and longevity science.

Episode metadata supplied by the publisher feed · Published Aug 13, 2025

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Neddylation: The Hidden Switch of Neuronal Aging with Dr.Nathalie Saurat

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