NEJM 9 10 2026 Complete Revascularization Guided by Functional Coronary Angiography in STEMI

This study explores how doctors can best provide complete revascularization for heart attack patients who have blockages in multiple arteries. By comparing two different diagnostic approaches, the researchers discovered that using functional coronary angiography—which assesses the actual physiological impact of a blockage—significantly outperforms traditional visual inspection. Patients whose treatment was guided by this physiology-based strategyexperienced a notably lower risk of major complications, such as death or subsequent heart attacks, compared to those evaluated through standard angiography. Ultimately, the trial demonstrates that targeting lesions based on their functional significance leads to safer and more effective outcomes for high-risk cardiac patients.