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NEJM This Week — December 18, 2025

Podcast of news and medicine from the NEJM.

Episode 24 of the NEJM This Week podcast, hosted by The New England Journal of Medicine, titled "NEJM This Week — December 18, 2025" was published on December 17, 2025 and runs 23 minutes.

December 17, 2025 ·23m · NEJM This Week

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We discuss the latest in medical research and ideas.

This week, we look at ctDNA-guided immunotherapy for bladder cancer, cardiovascular outcomes with tirzepatide, and evidence that one HPV vaccine dose may be enough. We explore high-dose rifampin for tuberculous meningitis, review measles amid rising outbreaks, and follow a challenging case of gastrointestinal bleeding. Essays examine how clinicians navigate post-Dobbs care, tobacco harm among people with mental illness, congenital syphilis, and sustaining medical research.

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