Neuroleptic Malignant Syndrome

Neuroleptic Malignant Syndrome is a life threatening reaction to antipsychotic (neuroleptic) medication. In this video we look at the pathophysiology, symptoms, diagnosis, differentials (including serotoning syndrome) and treatmentPDFs available here: https://rhesusmedicine.com/pages/psychiatryConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Neuroleptic Malignant Syndrome?0:33 Typical vs Atypical Antipsychotics 1:37 Neuroleptic Malignant Syndrome Pathophysiology2:32 Neuroleptic Malignant Syndrome Symptoms3:39 Risk Factors 4:52 Neuroleptic Malignant Syndrome Diagnosis6:00 Neuroleptic Malignant Syndrome Differential Diagnosis6:14 Neuroleptic Malignant Syndrome Treatment 7:40 Neuroleptic Malignant Syndrome ComplicationsLINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesBMJ Best Practice, 2025. Neuroleptic malignant syndrome. [online] Available at: https://bestpractice.bmj.com/topics/en-gb/990.StatPearls, 2025. Neuroleptic Malignant Syndrome. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK482282/.Wikipedia, 2025. Neuroleptic malignant syndrome. [online] Available at: https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome.National Center for Biotechnology Information (NCBI), 2025. Introduction - First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK107237/.MDedge Psychiatry, 2025. Identify neuroleptic malignant syndrome with FEVER. [online] Available at: https://www.mdedge.com/psychiatry/article/60368/identify-neuroleptic-malignant-syndrome-fever.Disclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.