NFL Week 1 Favorites Face Real Upset Risk

Picking NFL Week 1 favorites is easy; trusting them before we know what the 2026 versions of these teams really are is the risk. Drew and Rob put the full Week 1 slate on the record, looking for where the favorite deserves the confidence and where the underdog has a real path to wreck the obvious pick.Follow on Spotify and leave a 5-star rating on Apple Podcasts if you enjoy no-BS Giants debate.Which NFL Week 1 favorites are most vulnerable to an upset? Buffalo, Kansas City, Minnesota and Chicago all gave Drew and Rob reasons to question the favorite, while both hosts backed the Giants to beat Dallas outright at MetLife.The episode starts with Cowboys-Giants, where the latest injury news is encouraging, Matt Nagy is heading to the booth to call plays and Drew and Rob both believe the John Harbaugh era can begin with a win over Dallas. They also hit Harbaugh's game-by-game captain approach, C.J. Okoye, Dominic Zvada and the latest Giants news before moving across the league.Houston's defense creates one of the strongest upset cases of Week 1 against Josh Allen and Buffalo. Denver-Kansas City splits the hosts as Patrick Mahomes returns against a dangerous Broncos pass rush. Packers-Vikings brings another disagreement with Kyler Murray making his Minnesota debut, while Bears-Panthers becomes one of the games Drew and Rob think could decide their Week 1 picks battle.They also work through Buccaneers-Bengals, Falcons-Steelers, Jets-Titans, Saints-Lions, Commanders-Eagles, Ravens-Colts, Browns-Jaguars, Dolphins-Raiders and Cardinals-Chargers. Straight-up winners, spreads, totals, injuries and matchup advantages all go on the record before kickoff.Which favorite survives the hype, and which one walks directly into the first major upset of the 2026 NFL season?Merch: https://2giantgoofballs-shop.fourthwall.com/ Support: https://buymeacoffee.com/2giantgoofballs All episodes: https://2giantgoofballs.buzzsprout.com/Send us Fan MailSupport the show