Non-immune hydrops fetalis (NIHF): more than one entity

This podcast outlines the comprehensive evaluation and management of non-immune hydrops fetalis (NIHF), a condition where pathological fluid accumulates in at least two fetal compartments. Genetic disorders and structural anomalies are the primary causes, and advanced diagnostic testings like chromosomal microarray and exome sequencing are prerequisite. Clinicians are advised to monitor for maternal risks, particularly mirror syndrome, which mimics severe preeclampsia and may necessitate urgent delivery. Management strategies should be highly individualized, incorporating multidisciplinary counseling to address potential fetal therapies or palliative care. Ultimately, the guidelines prioritize shared decision-making regarding the timing and mode of delivery based on the underlying etiology and the pregnant person's preferences.