Obgyn: Endometrial Cancer: Free MSRA Podcast

🎙️ MSRA Deep Dive: Endometrial Cancer – Symptoms, Risks, Diagnosis & Treatment👩‍⚕️ In this focused episode, we break down endometrial cancer — the most common gynaecological malignancy — using high-yield revision notes designed for the MSRA. We simplify everything from risk factors to diagnosis, staging, and management.Whether you're revising for the MSRA or just brushing up on women’s health, this is your structured, exam-friendly review.📌 Main Topics Covered🔹 Definition & TypesCancer of the endometrial liningType 1: Oestrogen-dependent (better prognosis)Type 2: Oestrogen-independent (more aggressive)🔹 Risk Factors🔺 Age >50, postmenopause🔺 Obesity → ↑ endogenous oestrogen🔺 Nulliparity, early menarche, late menopause🔺 PCOS, unopposed oestrogen therapy🔺 Tamoxifen use🔺 Lynch syndrome (HNPCC), diabetes🔹 Protective Factors✅ Combined oral contraceptive pill (COCP)✅ Parity📌 Key Clinical Features🚨 Postmenopausal bleeding (PMB) = hallmark symptom91% of endometrial cancer cases present with PMB9% of PMB cases are due to cancerOther signs:Irregular bleeding (premenopause)Pelvic pain or mass (late stage)Unexplained weight loss, fatigue, leg swelling🩺 Investigations🔍 Transvaginal ultrasound (TVUS): Endometrial thickness >3–5mm🔬 Endometrial biopsy (via pipelle or hysteroscopy)📸 MRI/CT for staging💉 CA-125 may support but not diagnostic🎯 FIGO StagingStage I: Confined to uterusStage II: Involves cervixStage III: Pelvic spreadStage IV: Distant spread (lungs/liver)🧪 Grading (G1–G3)G1 = well-differentiatedG3 = poorly differentiated, high-risk💊 Management Overview🛠️ Surgical:Total hysterectomy + bilateral salpingo-oophorectomy (BSO)Lymph node dissection (if indicated)Laparoscopic surgery increasingly common🔆 Adjuvant therapy:Radiotherapy (esp. stage II–III)Chemotherapy (e.g., platinum-based for advanced or recurrent cases)Hormonal therapy: Progesterone for early-stage/low-grade in fertility-preserving cases🧬 Advanced Options:Pembrolizumab + lenvatinib combo for recurrent/metastatic cases post-platinum📉 PrognosisStage I → >95% 5-year survivalStage III → ~68%Stage IV → ~17%Most recurrences happen within 3 yearsObesity linked to poorer long-term outcomes🛠️ Useful MSRA Resources📘 Endometrial Cancer Notes:https://www.passthemsra.com/topic/endometrial-cancer-revision-notes/🧠 Flashcards:https://www.passthemsra.com/topic/endometrial-cancer-flashcards/🗂️ Accordion Q&A:https://www.passthemsra.com/topic/endometrial-cancer-accordion-qa-notes/🎯 Rapid Quiz:https://www.passthemsra.com/topic/endometrial-cancer-rapid-quiz/🧪 Quiz Bank:https://www.passthemsra.com/quizzes/endometrial-cancer/🎓 Full Course – Obs & Gynae for MSRA:https://www.passthemsra.com/courses/obstetrics-and-gynaecology-for-the-msra/📢 Hashtags#MSRA #MSRARevision #EndometrialCancer #PostmenopausalBleeding #MSRAPodcast #ObsAndGynae #MSRAFlashcards #MSRAQandA #MSRAHighYield