One Less, One More

This release contains only the music track from Base by Base Episode 457. Song title: One Less, One MoreOriginal Base by Base episode: 457: A deletion that raises Alzheimer risk, a duplication that lowers it Article metadata:Article title: Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer riskJournal: The American Journal of Human GeneticsDOI: 10.1016/j.ajhg.2026.07.013Reference: Quenez O, Schramm C, Cassinari K, Nicolas A, Groeneveld J, Huguet G, et al. Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk. The American Journal of Human Genetics. 2026;113(10):1-19. doi:10.1016/j.ajhg.2026.07.013 Lyrics:Verse 1Twenty-two thousand read.Every letter, every gap.One little stretch of twenty-twokept showing on the map. Pre-ChorusOne side heading down.One side climbing up.Same short street, same short block —different measure in the cup. ChorusONE LESS — and the risk goes UP.ONE MORE — and it settles DOWN.Same little piece of the same little placeturning it around.ONE LESS — only in the early years.ONE MORE — easy in the crowd.Same little piece, read it twice:count it, count it out loud. Verse 2Not one deletion showedin nine thousand walking free.But the doubles kept on turning upright where you want to be. ChorusONE LESS — and the risk goes UP.ONE MORE — and it settles DOWN.Same little piece of the same little placeturning it around. BridgePut the gene back in the cell —it clears the plaque right up.That's the piece we can see so far.Rare is rare enough.It ain't a shield. It's a lean.It tilts you. It don't save.Some who carried two of themstill came the harder way. Final ChorusONE LESS — and the risk goes UP.ONE MORE — and it settles DOWN.Not a promise, just a tilt,but you take it when it's found.ONE LESS. ONE MORE.Same little piece, both ways.Count it once, then count again —that's the whole thing, right there.