Oxycodone: Synthetic Opioid Analgesic for Perioperative Pain

We are plunging into the pharmacology of oxycodone, a potent semi-synthetic opioid analgesic widely used in perioperative and chronic pain settings. We explore oxycodone's mechanism of action, pharmacokinetics, and pharmacodynamics We dissect its action on mu-opioid receptors, compare it to morphine and other opioids, and review evidence regarding oral vs intravenous formulations, metabolism via CYP450 enzymes + implications for renal and hepatic impairment. It's lost is license for prolonged release versions in acute pain! Show notes at: https://gasgasgas.uk/oxycodone-for-the-frca-primary/ ================================================ GasGasGas - Covering Anaesthetic Science for Anaesthetists! Sponsored by Teach Me Anaesthetics Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate] Contributions to keep the lamps lit here ================================================ Dr Gas Lurks On:  > BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social) > X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X > FaceBook: Facebook - Gas Gas Gas > Website: www.gasgasgas.uk ================================================ Disclaimer / Sage Advice > All content is educational in nature and never intended to be acted upon. > This information is not a suitable substitute for medical advice. > Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed.  > Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present. ================================================ Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive  Sassy Jazzy - La Faena - Free music archive ================================================ "This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder." © GasGasGas-Podcast 2025