P2Y12 Inhibitors (ADP Inhibitors): Antiplatelet Pharmacology Made Easy episode artwork

EPISODE · Jan 16, 2026 · 44 MIN

P2Y12 Inhibitors (ADP Inhibitors): Antiplatelet Pharmacology Made Easy

from This Is Why with Dr. Busti · host Anthony Busti, MD, PharmD, MSc, FNLA, FAHA

In this lesson on P2Y12 inhibitors (ADP inhibitors), you’ll learn the high-yield, test-relevant concepts behind the most common antiplatelet drugs used in cardiovascular care. In this lecture from This is Why, Dr. Busti will break down how platelet aggregation inhibitors work, when they’re used clinically, and the key differences between clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), and cangrelor (Kengreal)—so you can apply the “why” behind therapy (not just memorize drug names).You’ll learn how to:- The P2Y12 (ADP) receptor and how blocking it reduces platelet activation- Where P2Y12 inhibitors fit in dual antiplatelet therapy (DAPT)- High-yield uses: acute coronary syndrome (ACS), PCI/stents, and secondary prevention- Major adverse effects (including bleeding) and top safety pearls- The exam-favorite comparisons: prodrug activation, onset/offset, reversibility, and IV vs PO optionsThe goal = make medical education easy and clinically relevant.Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/p2y12-adp-inhibitors-antiplatelet-pharmacology-reviewGet more with a free membership at https://www.thisiswhy.health/- Access free downloads from our videos - Access deep dive content from Dr. Busti- Organize content via playlists & collections- Join live Q&A- Receive member newsletters- Coupons & discounts for exam prep resourcesIf this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!#p2y12inhibitors #clopidogrel #antiplateletpharmacology #ticagrelor #drbustiDisclaimer:This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

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In this lesson on P2Y12 inhibitors (ADP inhibitors), you’ll learn the high-yield, test-relevant concepts behind the most common antiplatelet drugs used in cardiovascular care. In this lecture from This is Why, Dr. Busti will break down how platelet aggregation inhibitors work, when they’re used clinically, and the key differences between clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), and cangrelor (Kengreal)—so you can apply the “why” behind therapy (not just memorize drug ...

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P2Y12 Inhibitors (ADP Inhibitors): Antiplatelet Pharmacology Made Easy

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