Pablos Holman, Founder, Deep Future, on Why One Blood Test Could Predict What Kills You

Pablos Holman - hacker, Blue Origin alum, co-founder of a 6,000-patent invention lab with Bill Gates and Nathan Myhrvold, and now founder of the venture fund Deep Future - joins Jim Joyce and Eugene Borukhovich for a long-format conversation that starts in an Alaska basement and ends in a proteomic blood test that can already predict what kills you. Along the way: why he coined the term "shallow tech" for the last two decades of Silicon Valley, why the invention labs before his kept under-commercializing their own breakthroughs, and his case for why healthcare needs to work like Amazon and Google Maps combined before any of the rest of it matters. 00:00 - Cold Open - Letting Pablos In02:36 - Why This One's Different: The Long-Format Experiment03:21 - Born in Alaska With a Computer Nobody Had Seen10:23 - The Reverse-Engineering Mantra17:06 - What a Hacker Actually Is26:27 - From Dot-Com Bust to Blue Origin30:29 - Inventing 6,000 Patents With Bill Gates and Nathan Myhrvold36:21 - Why Invention Capital Beats Traditional VC43:49 - The Gwynne Shotwell Problem50:31 - The Case for Paying Inventors Like Musicians54:13 - Healthcare's 18 Trillion Dollar Problem59:11 - Alden Scientific: One Blood Test to Predict What Kills You1:03:12 - The Amazon-and-Google-Maps Vision for Healthcare1:06:40 - 3D-Printed Food, Revisited a Decade Later1:12:35 - Holobiome and the Return of Microbiome Science1:15:26 - AI, Hammers, and Who Should Decide What Matters1:20:33 - The Signature Question: Advice to His Younger Self1:29:05 - Where to Find Pablos Guest: Pablos Holman, Founder, Deep Future - LinkedIn - deepfuture.tech Mentioned in this episode: Blue Origin, Intellectual Ventures, Alden Scientific, Holobiome, Gwynne Shotwell (SpaceX), Neal Stephenson. If you enjoyed this episode, subscribe and leave a review - it's the easiest way to help more people find the show.