Paediatrics: Coeliac Disease: Free MSRA Podcast

⚕️ FREE MSRA PODCAST – Coeliac Disease🎧 A clear, high-yield breakdown of this autoimmune gluten intolerance – perfect for exam prep and real-life clinical scenarios.🧠 Key Learning Points📌 Definition• Coeliac disease is a chronic autoimmune condition triggered by gluten ingestion• Causes inflammation and villous atrophy in the small intestine → malabsorption📌 Causes & Risk Factors• Autoimmune response to gluten (wheat, barley, rye)• Strong genetic link: HLA-DQ2 or HLA-DQ8• Risk factors:– Family history– Type 1 diabetes– Down or Turner syndrome– IgA deficiency💡 Mnemonic: GROWTH – Genes, Rye/Wheat, Other conditions, Weak IgA, Twins, Heredity📌 Pathophysiology• Gluten ingestion triggers immune response → damages villi• Leads to flattening of villi (villous atrophy)• ↓ Absorption of nutrients → systemic symptoms📌 Symptoms• Diarrhoea, bloating, weight loss• Fatigue, anaemia, delayed puberty• Dermatitis herpetiformis (itchy rash)• In children: failure to thrive, bloated abdomen💡 Mnemonic: ABCD – Anaemia, Bloating, Coeliac rash, Diarrhoea📌 Differential Diagnosis• IBS• Crohn’s disease• Non-coeliac gluten sensitivity• SIBO• Wheat allergy• Lactose intolerance📌 Diagnosis• IgA-TTG and total IgA (first-line)• EMA or IgG-based tests if IgA deficient• Endoscopy with duodenal biopsy confirms diagnosis• 🧠 Tip: Keep eating gluten throughout testing💡 Mnemonic: "No Gluten-Free Before B&B" – Bloods & Biopsy📌 Management• Lifelong gluten-free diet (Wheat, Barley, Rye – NO oats unless GF certified)• Dietician referral + patient education• Monitor TTG levels + nutritional status• Bone health: consider DXA in high-risk patients• Support groups for education and adherence💡 Mnemonic: WBRNO – Wheat, Barley, Rye, No Oats📌 Complications• Osteoporosis• Infertility• GI malignancy (e.g. lymphoma)• Hyposplenism• Neurological symptoms (ataxia, neuropathy)• Coeliac crisis (rare, severe)📌 Prognosis• Excellent with strict GFD adherence• Symptoms improve, normal life expectancy possible• Poor adherence → ↑ risk of complications📎 More MSRA Resources for Coeliac Disease📝 Revision Notes: https://www.passthemsra.com/topic/coeliac-disease-revision-notes/🧠 Flashcards: https://www.passthemsra.com/topic/coeliac-disease-flashcards/💬 Accordion Q&A Notes: https://www.passthemsra.com/topic/coeliac-disease-accordion-qa-notes/🚀 Rapid Quiz: https://www.passthemsra.com/topic/coeliac-disease-rapid-quiz/🎓 Full Course: https://www.passthemsra.com/courses/paediatrics-for-the-msra/#MSRA #MSRARevision #MSRATextbook #MSRAQuiz #MSRAQuestionBank #MSRAFlashcards #MSRAQ&ANotes #MSRAAccordions #MultiSpecialityRecruitmentAssessment #MSRAOnlineRevision #MSRARevisionWebsite #CoeliacDisease #PaediatricsMSRA