Paediatrics: Cow's Milk Protein Intolerance and Allergy (CMPA): Free MSRA Podcast

⚕️ FREE MSRA PODCAST – Cow’s Milk Protein Allergy (CMPA)🎧 A clear, high-yield breakdown of this common infant food allergy – perfect for exam prep and real-life clinical scenarios.🧠 Key Learning Points📌 Definition• CMPA is an immune-mediated hypersensitivity to cow’s milk proteins (casein, whey).• Divided into IgE-mediated (immediate) and non-IgE-mediated (delayed) types.📌 Causes & Risk Factors• Family history of atopy (eczema, asthma, hay fever)• Formula feeding (vs. exclusive breastfeeding)• Early cow’s milk introduction• Other food allergies🧠 Mnemonic: F.A.S.T. = Formula-fed, Atopy, Soy cross-reactivity, Timing (early exposure)📌 Pathophysiology• IgE type: Sensitisation → IgE production → histamine release• Non-IgE: Delayed T-cell mediated inflammation of gut/skin📌 Symptoms• IgE: Rapid onset – urticaria, angioedema, wheeze, vomiting, anaphylaxis• Non-IgE: Delayed – reflux, colic, diarrhoea, eczema flare🧠 Mnemonic: G.S.R. = Gut, Skin, Respiratory symptoms📌 Differential Diagnosis• Lactose intolerance (non-immune)• GORD• Eosinophilic oesophagitis• Other food allergies• Infections (e.g. UTI)• Cystic fibrosis, pancreatic insufficiency📌 Diagnosis• History is key• IgE: Skin prick or specific IgE blood tests• Non-IgE: Elimination for 2–4 weeks → Symptom improvement → Rechallenge🧠 Tip: No reliable test for non-IgE – rely on clinical improvement📌 Management• Formula-fed:First-line: Extensively hydrolysed formula (EHF)Severe: Amino acid formula (AAF)• Breastfed: Continue breastfeeding + maternal dairy elimination• Dietician input essential• Milk ladder for reintroduction• Avoid soy and goat’s milk in early stages🧠 Mnemonic: F.A.D.S. = Formula, Avoidance, Dietician, Stepwise reintroduction📌 Complications• Failure to thrive• Nutritional deficiencies (calcium, vit D)• Psychosocial stress for families• Risk of anaphylaxis in IgE cases if re-exposed📌 Prognosis• Most resolve by age 3–5• Non-IgE tends to resolve earlier• IgE type may persist longer – supervised challenges required📎 More MSRA Resources for Cow’s Milk Protein Allergy (CMPA)📝 Revision Notes:https://www.passthemsra.com/topic/cows-milk-protein-intolerance-allergy-revision-notes/🧠 Flashcards:https://www.passthemsra.com/topic/cows-milk-protein-intolerance-allergy-flashcards/💬 Accordion Q&A Notes:https://www.passthemsra.com/topic/cows-milk-protein-intolerance-allergy-accordion-qa-notes/🚀 Rapid Quiz:https://www.passthemsra.com/topic/cows-milk-protein-intolerance-allergy-rapid-quiz/🎓 Full Course:https://www.passthemsra.com/courses/paediatrics-for-the-msra/#MSRA #MSRARevision #MSRATextbook #MSRAQuiz #MSRAQuestionBank #MSRAFlashcards #MSRAQandANotes #MSRAAccordions #MultiSpecialityRecruitmentAssessment #MSRAOnlineRevision #MSRARevisionWebsite #Paediatrics #CowsMilkProteinAllergy #CMPA