Pancreatic Cancer Breakthrough: The Pan-RAS Inhibition Era

Drs. Nicholas Hornstein, Timothy Brown, and Udhayvir Grewal break down the blockbuster press release from Revolution Medicine regarding their Phase 3 trial, RASOLUTE 302. For years, KRAS was the "compact, smooth" molecule that defied targeted therapy, but the era of the molecular glue has officially arrived.               Understanding the Breakthrough: The hosts emphasize the shift from "OFF" inhibitors to "ON" inhibitors. The following visual concept illustrates how these new molecular glues utilize a chaperone to finally lock onto the active state of the KRAS protein.   Chapters: 00:00 Press Release Breakthrough 01:21 Why KRAS Was Undruggable 03:14 Limits of G12C Inhibitors 08:43 Trial Results 13:58 What It Means for Patients 20:30 Oncoderm and Support Team 20:56 Whats Next in Trials   You can find us on X: Gut Onc Lab (@TheGutOncLab) / X