‘Pangenome’ aims to capture the breadth of human diversity

In this episode:00:45 Making a more diverse human genomeThe first draft of the human genome ushered in a new era of genetics research. Since its publication, researchers have constructed ever more accurate ‘reference genomes’ – baselines against which others are compared. But these are based on the DNA of a small number of people, and don’t represent the genetic variation known to exist across human populations. To address this, a consortium of researchers have published the first draft of a ‘pangenome’, which combines the genomes of 47 genetically diverse individuals. This draft provides a more complete picture of the human genome, and is the starting point for a project that aims to include sequences from 350 individuals.Research article: Liao et al. Research article: Vollger et al.Research article: Guarracino et al.News and Views Forum: Human pangenome supports analysis of complex genomic regions08:33 Research HighlightsA wearable sensor that lets users see infrared light, and how a vulture’s culture can influence its dining habits.Research Highlight: Wearable sensor gives a glimpse of ‘invisible’ lightResearch Highlight: What drives a scavenger’s diet? Vulture culture11:06 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, a new phosphate-storing organelle found in fruit fly cells, and how extracted DNA revealed who held a deer-tooth pendant 20,000 years ago.Nature News: New cellular ‘organelle’ discovered inside fruit-fly intestinesNature News: Prehistoric pendant’s DNA reveals the person who held itSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.