Part 3 — Getting Attached to Molecular Glues

Protein-protein interactions facilitate numerous bodily processes – everything from the basics of how our muscles contract to the more complex ways cancer can spread through the body. So, what if there was a way to alter some of these interactions? Or even create new ones?In this episode, we’re diving into the fascinating field of molecular glues, a revolutionary modality on the precipice of changing the treatment landscape for certain cancers and potentially other diseases and conditions. Featured Guests:– Joyann Donaldson, Principal Scientist, Synthesis Group Lead, Pfizer– Jennifer LaFontaine, Head of Oncology Medicinal Chemistry, Pfizer– Neal Sach, Research Fellow, Pfizer– Jillian Spangler, Associate Research Fellow, PfizerDive into the episode here:0:50 - A metaphor to explain molecular glues2:36 - How do molecular glues work in the body?5:57 - A new frontier for cancer treatment 13:05 - The history behind molecular glues16:59 - How do scientists design molecular glues?19:05 - A visit to Pfizer’s La Jolla labs32:42 - How can molecular glues change the patient experience?36:42 - Molecular glues beyond cancer treatmentSeason 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.