Part 4, The Story of the Antibody: Two Arms and a Stick

from Healio Rheuminations · host Adam J. Brown, MD

The last episode in the series highlighting how the structure of the antibody was discovered, as well as how a chicken butt was critical in understanding B cell biology. Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com Intro :11 In this episode :15 Recap: What we know about the antibody so far 1:12 Discovering the structure of the antibody 3:34 What else can we learn about the light chain 7:04 An understanding of what these proteins were 9:49 Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com. A story about a chicken butt 11:40 Backtracking to 1898 – where do antibodies come from? 16:49 An important paper in 1945 argues the lymphocyte is the antibody maker 18:59 Where is the bursa of Fabricius in humans? 20:46 A study from Australia 21:48 The bone marrow is what did it 23:00 Thanks for listening! 24:48 Disclosures: Brown reports no relevant financial disclosures. We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum References: Black CA. Immunol Cell Biol. 1997;doi: 10.1038/icb.1997.10. Coons AH, et al. J Exp Med. 1955;102:49-60. Cooper MD. Nat Rev Immunol. 2015;191-197. Edelman GM. J Am Chem Soc. 1959;81:3155-3156. Ehrich WE, Harris TN. Science. 1945;101:28-31. Fagraeus A. J Immunol. 1948;58:1-13. Glick B, et al. Poultry Sci. 1956;35:224-225. Osmond DG, Nossal GJ. Cell Immunol. 1974;13:132-145. Porter RR. Biochem J. 1959;73:119-126. Ryser JE, Vassalli P. J Immunol. 1974;113:719-728.

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