EPISODE · Oct 25, 2025 · 59 MIN
Patti Degnan, a16z Partner on CISO Leadership & Security Innovation
from Venture with Grace · host Grace Gong
Patti Degnan is a seasoned cybersecurity executive, venture investor, and operator. She recently joined Andreessen Horowitz (a16z) as a Partner (Operating Partner, CISO/CIO Advisor), where she oversees security-portfolio initiatives, engages with the CISO community, and forges strategic relationships across the industry. Prior to a16z, Patti served as the first Security hire and Chief Information Security Officer at Notion, where she built the security organization end-to-end—scaling it to 60+ individuals and supporting 100 million+ user sign-ups across security operations, product security, infrastructure security, governance, risk and compliance (GRC), privacy, and trust engineering. With her unique transition from operator to investor, Patti brings deep hands-on experience and strategic insight to help founders and CISOs build secure, scalable, and resilient organizations.Topics: Building Security at ScaleFrom CISO to VC Partner AI x Security#AISecurity #CybersecurityLeadership #a16z #ResponsibleAI #TechInnovation
What this episode covers
Patti Degnan is a seasoned cybersecurity executive, venture investor, and operator. She recently joined Andreessen Horowitz (a16z) as a Partner (Operating Partner, CISO/CIO Advisor), where she oversees security-portfolio initiatives, engages with the CISO community, and forges strategic relationships across the industry. Prior to a16z, Patti served as the first Security hire and Chief Information Security Officer at Notion, where she built the security organization end-to-end—scaling it to 60+ individuals and supporting 100 million+ user sign-ups across security operations, product security, infrastructure security, governance, risk and compliance (GRC), privacy, and trust engineering. With her unique transition from operator to investor, Patti brings deep hands-on experience and strategic insight to help founders and CISOs build secure, scalable, and resilient organizations.Topics: Building Security at ScaleFrom CISO to VC Partner AI x Security#AISecurity #CybersecurityLeadership #a16z #ResponsibleAI #TechInnovation
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Patti Degnan, a16z Partner on CISO Leadership & Security Innovation
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