PCOS, Endometriosis, & Designing Supplements for Women | Ep. 11 (ft. Prof. Siobhain O'Mahony) episode artwork

EPISODE · Jun 11, 2026 · 44 MIN

PCOS, Endometriosis, & Designing Supplements for Women | Ep. 11 (ft. Prof. Siobhain O'Mahony)

from Straight Talking Science · host Shane O'Callaghan

What if the painful periods, mood swings, and chronic fatigue you've been told to just "deal with" are actually signs of something bigger? Professor Siobhain O'Mahony returns to unpack the hidden connections between your gut microbiome, hormones, and the most misunderstood conditions in women's health. From endometriosis affecting 1 in 10 women to polycystic ovarian syndrome impacting 1 in 5, these aren't just fertility issues. They're complex, hormone driven syndromes that disrupt metabolism, mood, sleep, and quality of life. Yet diagnosis takes years, treatment is fragmented, and women are left managing symptoms in isolation. Siobhain reveals why your gut bacteria might be recycling too much estrogen, how insulin resistance drives PCOS, and why fiber isn't just for digestion. This is women's health through the lens of cutting edge microbiome science, and it changes everything. Topics covered: Why women's pain gets split into the wrong boxes and misdiagnosed for years Endometriosis: what it is, why it takes 7 to 10 years to diagnose, and the role of visceral pain Polycystic ovarian syndrome: the insulin resistance connection and why it's not just about fertility Adenomyosis and fibroids: how they differ from endometriosis and why they matter The estrobolome: your gut bacteria that recycle estrogen and why that's not always a good thing How to manipulate your microbiome to support hormone balance and clearance The role of fiber: psyllium husk, oats, flaxseeds, and why not all fiber is the same Why your liver and gut health are critical for managing hormone related conditions The missing research: why women's gut health has been overlooked in favor of vaginal microbiome studies Fembiome: designing microbiome targeted supplements with women, for women The science behind their perimenopause supplement and why clinical trials matter Why women need to be included in clinical research across all life stages The EU endometriosis grant: defining baseline microbiome health before surgery or hormone therapy One symptom women should never ignore: chronic fatigue The question every woman should ask her doctor: could my diet be part of the problem? Why young women and men need to be educated about PCOS and endometriosis in schools How to get involved in women's health research and why your voice matters The bottom line? Women's health is not just about fertility. It's about hormones, metabolism, pain, mood, and the gut microbiome that ties it all together. If you've been told your symptoms are normal or that you just need to push through, it's time to ask better questions. Mind your microbiome, prioritize fiber, support your liver, and don't ignore chronic fatigue. You deserve answers, not dismissal. The science is here. Now it's time to use it. Check out Femmebiome here: https://femmebiome.com/ Website: https://atlantiaclinicaltrials.com/ LinkedIn: https://ie.linkedin.com/company/atlantia-clinical-trials Instagram: https://www.instagram.com/atlantia_clinicaltrials/ Meta: https://www.facebook.com/AtlantiaClinicalTrials/ Check out Straight Talking Science on Spotify: https://open.spotify.com/show/5vdjz93jVdKlY0Arl6rQ7Z #WomensHealth #Endometriosis #PCOS #GutMicrobiome #Estrobolome #HormoneHealth #SciencePodcast #FemTech #ClinicalResearch

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PCOS, Endometriosis, & Designing Supplements for Women | Ep. 11 (ft. Prof. Siobhain O'Mahony)

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