EPISODE · Sep 5, 2026 · 34 MIN
Peptide Doctor Gives a Peptide Masterclass
from Dr. Paika Podcast · host Mohammed Paika
#Peptides #PeptideTherapy #GLP1 #AntiAgingMedicine #bpc157 Peptides didn't start with a wellness influencer — they started with a dying 14-year-old boy in 1922 and a shot of insulin. Today that same category includes everything from FDA-approved medications to unregulated research chemicals sold online with zero oversight.In this video I break down over 20 peptides — from BPC-157 and TB-500 to semaglutide, tirzepatide, retatrutide, and the newest FDA regulatory update on compounding access — organized into the three levels of biology they actually work on: cellular energy, tissue repair, and systemic control (your hormones, metabolism, and nervous system).🎓 Complete GLP-1 Weight Loss Masterclass — Lifetime AccessComprehensive education on GLP-1 medications, nutrition, exercise, muscle preservation, side effects & long-term success. Includes the companion eBook, quizzes, 12-week exercise program, certificate & future course updates at no additional cost.https://www.drmohammedpaika.com📩 FREE GLP-1 Diet Cookbook + Weekly NewsletterGet weekly evidence-based insights on GLP-1s, metabolic health, nutrition, exercise & longevity.https://www.drmohammedpaika.com/newsletter📚 The Weight Equation & The Physician’s PhysiquePhysician-written, evidence-based guides to obesity, weight loss, nutrition, metabolism, exercise, body composition & healthier living.https://www.drmohammedpaika.com/books👥 Metabolic Health Communityhttps://www.skool.com/metabolic-health-community-5316TIMESTAMPS0:00 – Intro — why peptides aren't what you think1:21 – What a peptide actually is3:24 – Why "your body recognizes it" doesn't mean it's right for you5:15 – The three-layer framework6:18 – Layer One: Cellular energy (Epitalon, MOTS-c, SS-31)11:58 – Layer Two: Tissue repair (BPC-157, TB-500, GHK-Cu)18:08 – Layer Three: Hormones (Sermorelin, Ipamorelin, CJC-1295, Tesamorelin)21:36 – Layer Three: Metabolism (Semaglutide, Tirzepatide, Retatrutide)26:24 – Layer Three: Brain & nervous system (Semax, Selank, Dihexa, Cerebrolysin)31:40 – The most expensive mistake I see33:44 – What to do with thisReferencesWHO — Diabetes Fact Sheet: ~9 million people worldwide live with type 1 diabetes and require insulin injections for survivalNational Institute on Aging — "Exendin-4: From Lizard to Laboratory...and Beyond"PubMed — "The Development of Byetta (Exenatide) From the Venom of the Gila Monster" (PMID 21194543)Cell Metabolism (2015) — "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance"Khavinson, Bondarev, Butyugov — "Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells," Bulletin of Experimental Biology and Medicine, 2003Khavinson et al. — "Effect of Epitalon on Biomarkers of Aging, Life Span and Spontaneous Tumor Incidence in Female Swiss-Derived SHR Mice," Bulletin of Experimental Biology and MedicineJohns Hopkins ICTR; Pharmacy Times; Drugs.com — FDA accelerated approval of Forzinity (elamipretide/SS-31) for Barth syndrome, September 19, 2025Genetics in Medicine — Phase 2/3 randomized trial of elamipretide (SS-31) in Barth syndrome (PMC7935714)Pickart et al. — "Regenerative and Protective Actions of the GHK-Cu Peptide in the Skin and Other Tissues" (PMC6073405)USADA — Athlete Advisory on 2022 WADA Prohibited List changes (BPC-157)Sport Integrity Australia — Thymosin Beta-4 (TB-500) substance profilePharmaceutical Executive — "FDA Votes to Loosen Restrictions for Four Peptides" (July 23, 2026); STAT News coverage of the same PCAC vote (BPC-157 8-6, TB-500 8-6, KPV 8-6, MOTS-c 7-5 — advisory only, formal rulemaking still pending)CBS News — "Stallone Pleads Guilty to Import Charge" / "Australia Fines Sly for Toting Hormones" (2007); Hollywood Reporter (2007); Taipei Times wire report (May 22, 2007)FDA — Approved labeling for EGRIFTA (tesamorelin for injection)Jastreboff et al., New England Journal of Medicine, 2023 — Phase 2 trial of retatrutidePharmaceutical Journal / AJMC / Pharmacy Times, May 2026 — TRIUMPH-1 topline results (Eli Lilly; peer review pending)Alzheimer's Drug Discovery Foundation, Cognitive Vitality — Dihexa peptide profileNeurologyLive / FierceBiotech — Fosgonimeton LIFT-AD (Nov 2024) and SHAPE (Dec 2023) trials, both missed primary endpointZiganshina LE et al., Cochrane Database of Systematic Reviews, 2020 — Cerebrolysin for acute ischaemic stroke⚕️ MEDICAL & EDUCATIONAL DISCLAIMER: This content is for general educational and informational purposes only and is not medical advice or a substitute for care from your healthcare provider. Viewing this content does not create a doctor-patient relationship. Always consult a qualified healthcare professional before starting, stopping, or changing any medication, diet, exercise, or weight-loss plan. Individual results and risks vary. You assume responsibility for decisions made based on this content.
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