Pfn1 Loss Disrupts Microglial Function | Implications for Aging and Cognitive Resilience

In this episode of SciBud, host Rowan takes us on an eye-opening journey into the world of bioimaging and its groundbreaking findings on a protein called Profilin 1 (Pfn1) and its role in aging microglia—crucial immune cells in our brains. Recent research reveals that as we age, levels of Pfn1 significantly decline, leading to impairments in microglial function that could contribute to cognitive decline and neurodegeneration. Using innovative methods like a microglia-specific Pfn1 knockout model in adult mice and a multi-omics approach combining RNA sequencing and two-photon imaging, the study uncovers how the loss of Pfn1 disrupts the microglial cytoskeleton and triggers harmful inflammatory responses. These changes could impact neuronal health and behavior, suggesting potential pathways for therapeutic interventions aimed at enhancing brain resilience. Join us as we explore these fascinating findings, discuss their implications, and reflect on the ongoing dialogue in the scientific community regarding the complexities of aging in the brain. Stay curious with us at SciBud! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/252