Pharma 50: Motility, Flow, and Expulsion - Keeping Things Moving

This episode examines gastrointestinal motility and fluid handling as the pharmacology of directed movement. From oesophageal peristalsis to colonic propulsion, from secretion to absorption, the gut is a finely tuned conveyor system. We explore the enteric nervous system, smooth-muscle signalling, and epithelial transport to understand disorders of diarrhoea, constipation, nausea, vomiting, and biliary or pancreatic dysfunction. Therapeutic choices are framed around restoring direction and coordination, not merely stopping symptoms.Key takeaways to consolidate learning:* The enteric brain: autonomy with accountability to central signals.* Peristalsis and segmentation: propulsion versus mixing.* Fluid balance: secretion, absorption, and why small shifts have big effects.* Antiemetic logic: targeting triggers at the gut, blood, and brainstem.* Clinical strategy: choosing prokinetics, laxatives, antidiarrhoeals, and antiemetics by mechanism-not habit. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drmanaankarray.substack.com/subscribe