Phase 5: Restore brain volume and repair inflammation markers (Shoemaker Protocol Series) episode artwork

EPISODE · Jun 17, 2026 · 11 MIN

Phase 5: Restore brain volume and repair inflammation markers (Shoemaker Protocol Series)

from The CIRS Group Podcast · host thecirsgroup

Barbara and Jacie wrap up their five-part Shoemaker Protocol series with Phase 5: Repair and Restore. This phase focuses on normalizing innate immune markers (MMP-9, C3a, C4a, and TGFb1) and restoring brain volume. They explain that low-starch/gluten-free diet helps bring down MMP-9, while persistently elevated C3a/C4a or TGFb1 often signal ongoing exposure, gut issues, tick-borne illness, or dental cavitations. The episode culminates with VIP (vasoactive intestinal peptide) nasal spray (the most anticipated step of the entire protocol!) which supports anti-inflammatory pathways, neurological function, and brain volume restoration over 6–12 months. For more information and support, join us at https://thecirsgroup.com TIMESTAMPS 00:00 Introduction: Phase Five 01:24 Medical Disclaimer 01:55 Innate Immune Markers and VIP Nasal Spray 02:50 Understanding MMP-9 05:14 C3a and C4a Markers 07:20 TGFb1 08:18 VIP Spray Treatment 10:34 Closing Thoughts For more information and support, join us at https://thecirsgroup.com Order Jacie's book! The 30 Day Carnivore Bootcamp: https://a.co/d/7MgHrRs The CIRS Group: Support Community: https://thecirsgroup.com Instagram: https://www.instagram.com/thecirsgroup/ Find Jacie for carnivore, lifestyle and limbic resources: Jacie’s book on the Carnivore diet!  https://a.co/d/8ZKCqz0 Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a Shoemaker certified Proficiency Partner, NASM certified nutrition coach, author, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a business and fitness coach, CIRS and ADHD advocate, writer, speaker, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

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Phase 5: Restore brain volume and repair inflammation markers (Shoemaker Protocol Series)

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