Piperine: The molecule that makes everything else work better by inhibiting your liver

Piperine enhances curcumin bioavailability by 2,000%. It also enhances CoQ10, resveratrol, beta-carotene, and selenium absorption. The mechanism: it inhibits CYP3A4 and P-glycoprotein, the liver's main drug-metabolizing enzyme and the gut's efflux pump. Piperine doesn't help your body absorb more; it stops your body from clearing what you've already absorbed. This is the same mechanism that makes grapefruit juice dangerous with certain medications.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/9619120/https://pubmed.ncbi.nlm.nih.gov/18480186/https://pmc.ncbi.nlm.nih.gov/articles/PMC2574793/