PMS, Histamine & Hormones: What's Really Going On? episode artwork

EPISODE · Jun 9, 2026 · 26 MIN

PMS, Histamine & Hormones: What's Really Going On?

from Her Genetic Edge · host Lori Aikman | Her Genetic Edge

There's a viral trend going around — women taking Zyrtec, Claritin, and Pepcid before their periods and reporting that their PMS and PMDD symptoms are dramatically better. And honestly? It's working. But why?In this episode, I break down the real reason antihistamines are helping — and what it's actually telling you about what's going on inside your body. Because the trend is onto something. It's just not the whole story.We cover:How estrogen and progesterone directly control histamine release — and what happens when they fall out of balanceWhy histamine isn't just an allergy problem — and how it drives mood swings, anxiety, bloating, and migrainesThe feedback loop that keeps symptoms stuck and makes them worse over timeTwo key genetic variants that explain why you might struggle more than your sister, your friend, or the woman next to youWhat a root cause approach actually looks like — and where antihistamines fit inWhether you're in your 30s dealing with PMDD or in your 40s wondering why perimenopause is hitting differently than you expected — this episode will give you a framework for understanding what's really going on, and what's worth addressing first.Subscribe at LoriAikman.com so you don't miss what's coming next. Get full access to Lori Aikman | Her Genetic Edge at www.loriaikman.com/subscribe

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PMS, Histamine & Hormones: What's Really Going On?

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