EPISODE · Apr 30, 2026 · 4 MIN
Pomegranate: The most interesting thing about pomegranate is what your gut bacteria make from it
from NutraSift: The nutraceutical innovation podcast · host Siftlink SA
Pomegranate ellagitannins (punicalagins) are barely absorbed. Your gut microbiota converts them to urolithins, particularly urolithin A, which induces mitophagy (clearance of damaged mitochondria). This is one of the most validated mechanisms in longevity science. But only ~40% of people produce urolithin A efficiently. The fruit isn't the product; the metabolite is and most people can't make it.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/27400265/https://pubmed.ncbi.nlm.nih.gov/32694802/https://pubmed.ncbi.nlm.nih.gov/35118817/
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Pomegranate: The most interesting thing about pomegranate is what your gut bacteria make from it
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