Preparing for Biomarker-Directed Care in epNEC: What Pathologists Need to Know Now

This podcast features Dr David Klimstra discussing how pathologists can prepare for biomarker-directed care in extrapulmonary neuroendocrine carcinoma (epNEC). Key topics include accurate NEC classification before delta-like ligand 3 (DLL3) assessment, tissue stewardship, timing and location of immunohistochemistry testing, evolving scoring thresholds, and the importance of close pathology-oncology communication to support treatment decisions and emerging DLL3-directed strategies.