Psychedelics, Antidepressants, & Tapering Ft. Spirit Pharmacist, Dr. Ben Malcolm

Join host Jimmy Nguyen as he delves into the complex interplay between antidepressants and the world of psychedelics. In this episode, special guest Dr. Ben Malcolm, the Spirit Pharmacist, unlocks the secrets of his extensive background in public health and pharmacology.He provides a nuanced perspective on the variability in individual responses to co-administration of antidepressants and psychedelics, touching upon the complexity of conversion-related issues, absorption-related issues, and genetic variations in serotonin receptors.The episode delves into practical approaches for individuals on different classes of antidepressants who are contemplating a psychedelic experience. Dr. Malcolm introduces the concept of "dose testing," suggesting a gradual and cautious exploration starting with microdoses to assess sensitivity. The conversation addresses the challenges of tapering antidepressants, emphasizing the need for a personalized and gradual approach. Dr. Malcolm offers suggestions of what to avoid during tapering and how to safely explore individual tolerance to psychedelics.Key TakeawaysEvolution of Perception: The understanding of interactions between SSRIs and psychedelics has shifted dramatically in the past decade, dispelling the once prevalent notion of their deadly combination. This evolving perspective opens up therapeutic possibilities never thought possible before.Compatibility Insights: Different medications impact psychedelic experiences differently. While serotonergic medications like SSRIs may dampen typical psychedelic effects, substances like ketamine prove to be more compatible. Ayahuasca, with MAOIs, poses risks of serotonin syndrome when combined with serotonergic medications.Tapering Considerations: Tapering off antidepressants before a psychedelic experience is an individual choice, contingent on factors like the duration of medication use. Dr. Malcolm challenges aggressive tapering protocols, advocating for a more gradual, personalized approach. Additional Resources:Episode Blog PostThe Psilocybin-Blunting Effects of SSRIs and AntidepressantsSSRIs, Antidepressants, and PsilocybinShould I Stop Using Antidepressants For Psychedelic Therapy?This podcast is edited by Chad Eschman. Our music is by Mic Coats. Psychedelic Passage is your partner in safe, supported, and effective psychedelic journeys. As the first concierge service in the U.S., we connect you with vetted facilitators who value integrity and expertise.Start your free Match Making Process, join our Online Learning Community, and explore a range of educational articles at psychedelicpassage.com.