Rabies doesn't make them angry

This research explores the genomic adaptations of bats, focusing on their unique immune systems and viral reservoirs. The study sequenced and analyzed the genomes of ten bat species to construct a comprehensive phylogeny. Researchers investigated genes under positive selection, especially those related to immune functions, finding that bats exhibit a high prevalence of immune-related gene selection. Further analysis focused on ISG15, an interferon-stimulated gene, examining its structure, function, and antiviral activity in different bat species. Experiments revealed species-specific variations in ISG15's ability to form dimers and combat viral infections like SARS-CoV-2. The findings contribute to understanding bat immunity and its implications for zoonotic disease transmission. Source: Morales, A.E., Dong, Y., Brown, T. et al. Bat genomes illuminate adaptations to viral tolerance and disease resistance. Nature (2025). https://doi.org/10.1038/s41586-024-08471-0