Renal: IgA Nephropathy: Free MSRA Podcast

⚕️ FREE MSRA PODCAST – IgA Nephropathy🎧 A focused breakdown of this immune-mediated glomerular disease — perfect for MSRA prep and clinical recall!🧠 Key Learning Points📌 Definition• Also known as Berger’s Disease• Immune complex glomerulonephritis due to IgA deposition in the glomeruli• Most common cause of primary glomerulonephritis globally📌 Causes & Risk Factors• Multifactorial: genetic predisposition + immune dysregulation• Infections (especially respiratory or GI) trigger flare-ups• Male sex (2:1 ratio), Asian descent, family history• Associated with: coeliac disease, alcoholic liver disease, HSP, dermatitis herpetiformis📌 Pathophysiology• Abnormally glycosylated IgA1 → immune complex formation• Deposits in mesangium → mesangial activation, inflammation, fibrosis• Leads to glomerular scarring over time (Oxford classification: MEST)📌 Symptoms• Visible haematuria (especially after infections)• Microscopic haematuria, proteinuria, hypertension• Oedema, fatigue in more severe/progressive cases• Often asymptomatic early — picked up on routine urinalysis📌 Differential Diagnosis• Post-infectious GN• Lupus nephritis, HSP nephritis, membranoproliferative GN• Myeloma, HIV nephropathy📌 Diagnosis• Urinalysis: blood, protein, red cell casts• U&Es, eGFR, IgA levels (may be ↑ but not diagnostic)• Definitive: renal biopsy with IgA deposits (±C3) on immunofluorescence• Oxford MEST-C scoring = prognostic value• Consider serum electrophoresis if age >50📌 Management• Mild disease: monitor (if low proteinuria, normal BP/renal function)• If proteinuria >0.5–1g/day → ACEi or ARB (↓ proteinuria & protect kidney)• If progressing: corticosteroids (e.g. prednisolone)• Immunosuppressants only in rapidly progressive GN• Lifestyle: low salt diet, weight control, stop smoking• Rare cases: tonsillectomy (only if recurrent tonsillitis)• ESRD → dialysis or transplant (but disease may recur post-transplant)📌 Complications• Chronic kidney disease, end-stage renal failure• Hypertension, nephrotic syndrome, cardiovascular disease• Risk of recurrence post-transplant📌 Prognosis• Highly variable• Good: isolated haematuria, well-controlled BP, low proteinuria• Poor: male sex, proteinuria >1g/day, uncontrolled HTN, ↓ eGFR, Oxford score with S/T lesions• ~25–40% develop ESRD within 20 years📎 More MSRA Resources for IgA Nephropathy📝 Revision Notes:https://www.passthemsra.com/topic/lga-nephropathy-revision-notes/🧠 Flashcards:https://www.passthemsra.com/topic/lga-nephropathy-flashcards/💬 Accordion Q&A Notes:https://www.passthemsra.com/topic/lga-nephropathy-accordion-qa-notes/🚀 Rapid Quiz:https://www.passthemsra.com/topic/lga-nephropathy-rapid-quiz/🧪 Topic Quiz:https://www.passthemsra.com/quizzes/iga-nephropathy/🎓 Full Renal Course:https://www.passthemsra.com/courses/renal-for-the-msra/🩺 All resources are part of the Renal for the MSRA course on PassTheMSRA.com📚 Explore full revision guides, quizzes, flashcards, and more:https://www.passthemsra.comHashtags#MSRA #MSRARevision #MSRATextbook #MSRAQuiz #MSRAFlashcards #MSRAQandANotes #MSRAAccordions #Renal #IgANephropathy #BergerDisease #MSRAOnlineRevision #PassTheMSRA