Replacing Chemotherapy with a Gentler Process: Dr. Danielle Villars, ATLyphe

How one approaches the goal of replacing chemotherapy with a gentler process? Where does the “we can do it” start? How do you get to the point where your process shows no side effects in the pre-clinical phase, in animals? And when will clinical trials start – in patients?In this episode, you’ll hear abouthow are blood cells producedacute myeloid leukemiahematopoietic stem cell transplantation or bone marrow transplant procedurehow to replace chemotherapy in the conditioning stageATLyphe is a Swiss Startup, a spin-off from the ETH Zurich and the University of Zurich. They developed a T cell engager and activator for safer, precise conditioning before hematopoietic stem cell transplantation in leukemia.My guest today is Dr. Danielle Villars, the CEO of ATLYphe, a biologist who completed her PhD in cancer biology. She already proved she is a high achiever – before committing to science-backed entrepreneurship and bringing this new process to patients, she broke four national records as an Olympic swimmer for Switzerland.Here’s more about ATLyphe:https://www.atlyphe.com/Please note, the treatment is not yet available for patients.Timestamps:0:00 Dr. Danielle Villars and ATLyphe1:18 Aim: No Chemotherapy Side Effects 4:23 How Are Blood Cells Produced6:28 Gene Mutation in Acute Myeloid Leukemia11:00 How is Acute Myeloid Leukemia Treated Currently13:06 What Is the Hematopoietic Stem Cell Transplantation Process16:06 What is Conditioning before Blood Transplantation20:40 Immunotherapeutic Approach in Place of Chemotherapy27:16 What is Graft vs Host Disease29:27 Beginnings of ALY117 Immunotherapy for Conditioning37:21 Study Pathway before Patients Can Receive ALY117 45:20 Thank You, Follow ATLyphe45:48 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.