(Replay) Depression, Why does mad girlfriend ignore, 25 year relationship no sex

In today's replay of episode 206, Dr. Lisle & Dr. Howk go over the following questions: 1. Depression often gets talked about as being a biological condition and that just like having a broken arm, treating depression with medication is similar to treating a broken bone with a splint. What is the opinion of Dr. Lisle and Dr. Howk about treating depression with medication vs. taking an evolutionary approach to helping individuals improve the esteem dynamics in their life? The combination of medication and therapy is often viewed as the best treatment, but I don't think most therapies take the approach that Dr. Lisle and Dr. Howk do. 2. I'm a male and I've noticed that in numerous relationships, if my girlfriend was mad, then she would just flat out ignore me. I don't understand this behavior as anger would usually lead me to talk through issues and try to resolve them, whereas they might just ignore my calls and messages for days at a time. This caused me tremendous stress ro the point of getting no sleep and significantly impaired life functioning. How do I deal with this situation? And is this a male/female difference in conflict resolution, or an esteem dynamic where I'm over rewarded? 3. Ive been living with my boyfriend for over 15 yrs. Been with him total of 25 yrs. Im a young 60, he is 57. Ready to fall off ur chair? We have never had intercourse. First 10 yrs we done sone other intimate things, but no more. He never pursues or initiates anything with me. I used to try, but tired of being rejected.;( I want to leave the relationship. But do not. I definitely need help, can u give me some insight & guidance.