REPLAY: Neuroinflammation: Impacts on Immunity, Behaviour and Brain Function with Adrian Lopresti and Dr Austin Perlmutter episode artwork

EPISODE · Jun 2, 2025

REPLAY: Neuroinflammation: Impacts on Immunity, Behaviour and Brain Function with Adrian Lopresti and Dr Austin Perlmutter

from FX Medicine Podcast Central

Dr Austin Perlmutter, neurobiology, mood and decision-making expert, joins our ambassador Dr Adrian Lopresti as they explore the biological basis of “stuckness” in the mind and how the brain is influenced by inflammatory/immune triggers which results is certain behaviours and health outcomes. Together they discuss the relationship between sickness behaviour, neuroinflammation and their effect on the brain leading to our inherent tendency to return to “default”. Nature vs nurture is discussed where exposures from foetal development, childhood trauma and genetic influences can impact our mental and cognitive flexibility much later in life. Austin explains “disconnection syndrome” a modern conundrum where our brains tend to latch onto impulsive behaviours leading to cognitive decline. It’s not all doom and gloom as Austin and Adrian bring practical solutions to the table in the form of simple lifestyle adjustments that promotes behavioural change and reduce neuroinflammation. COVERED IN THIS EPISODE (00:55) Welcoming Dr Austin Perlmutter (01:42) Preventing chronic disease and reduced brain function (05:32) Sickness behaviour and the impacts of inflammation on the brain (08:48) How genetics and environment predispose us to increased risk of brain conditions (12:46) Does early life trauma increase our risk of developing mental health conditions? (15:28) The disconnection syndrome (18:57) Chronic stress induces brain atrophy (24:02) How inflammation impacts immunity (29:00) Connections between inflammation, impulsivity and decision making (35:07) Effects of inflammation on sleep and neuroplasticity (41:05) Food for brain health (48:34) Supplementation to improve brain function and reduce inflammation (51:24) Implementing lifestyle changes and resources for practitioners (56:00) Thanking Austin and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/neuroinflammation-impacts-on-immunity-behaviour-brain-function-with-dr-adrian-lopresti-dr-austin-perlmutter Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://login.bioceuticals.com.au ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

Dr Austin Perlmutter, neurobiology, mood and decision-making expert, joins our ambassador Dr Adrian Lopresti as they explore the biological basis of “stuckness” in the mind and how the brain is influenced by inflammatory/immune triggers which results is certain behaviours and health outcomes. Together they discuss the relationship between sickness behaviour, neuroinflammation and their effect on the brain leading to our inherent tendency to return to “default”. Nature vs nurture is discussed where exposures from foetal development, childhood trauma and genetic influences can impact our mental and cognitive flexibility much later in life. Austin explains “disconnection syndrome” a modern conundrum where our brains tend to latch onto impulsive behaviours leading to cognitive decline. It’s not all doom and gloom as Austin and Adrian bring practical solutions to the table in the form of simple lifestyle adjustments that promotes behavioural change and reduce neuroinflammation. COVERED IN THIS EPISODE (00:55) Welcoming Dr Austin Perlmutter (01:42) Preventing chronic disease and reduced brain function (05:32) Sickness behaviour and the impacts of inflammation on the brain (08:48) How genetics and environment predispose us to increased risk of brain conditions (12:46) Does early life trauma increase our risk of developing mental health conditions? (15:28) The disconnection syndrome (18:57) Chronic stress induces brain atrophy (24:02) How inflammation impacts immunity (29:00) Connections between inflammation, impulsivity and decision making (35:07) Effects of inflammation on sleep and neuroplasticity (41:05) Food for brain health (48:34) Supplementation to improve brain function and reduce inflammation (51:24) Implementing lifestyle changes and resources for practitioners (56:00) Thanking Austin and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/neuroinflammation-impacts-on-immunity-behaviour-brain-function-with-dr-adrian-lopresti-dr-austin-perlmutter Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://login.bioceuticals.com.au ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

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Dr Austin Perlmutter, neurobiology, mood and decision-making expert, joins our ambassador Dr Adrian Lopresti as they explore the biological basis of “stuckness” in the mind and how the brain is influenced by inflammatory/immune triggers which...

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