Restarting GLP-1s? 5 Reasons It Feels Harder This Time

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us. Back on your GLP-1 medication… but confused why it isn’t working this time?Lots of people stop these medications for valid reasons. Cost, side effects, pregnancy plans, or simply because things were going well and it felt like the right time to try managing without them. But when weight creeps back on and you restart, it can feel really frustrating when results don’t look the same.In this episode, I talk through why that happens. Factors like muscle loss, metabolism changes, weight regain patterns, and higher stress levels can all change how your body responds the second time around. If you’re feeling stuck or wondering what changed, this episode will help you make sense of what’s going on and figure out your next steps without beating yourself up.ReferencesGet the free podcast roadmap for The Obesity GuideJane Pilger: The GatheringA monthly guided experience to help you slow down and learn how to trust yourself.Slowing Down to the Speed of Joy by Matthew Kelly Back to Basics Mini Podcast Series 2025Ep. 100: HydrationEp. 101: ProteinEp. 102: FiberAudio Stamps00:30 - Why GLP-1 medications may stop working when you restart them after taking a break.01:20 - Book recommendation: "Slowing Down to the Speed of Joy" and how constant busyness prevents you from addressing behaviors that aren't serving you.04:04 - The common pattern: success, stopping medication, weight regain, then struggling when restarting.06:25 - Why it's harder the second time: muscle loss, weight cycling, and mismanaged expectations all impact your results.09:00 - The importance of updated lab work and comprehensive metabolic assessment before restarting.10:35 - How chronic stress and high cortisol prevent weight loss, even on medication.14:35 - The real work: learning nervous system regulation instead of constantly fighting cravings and urges.All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast. If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com Not Sure Where to Start With the Podcast? I’ve Got You.Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.Support the show